What is Soybean Extract Isoflavones?

Latin Name: Glycine max (L.) Merrill [Fam. Fabaceae]
Part Used: Bean
Extracted Ratio: 120:1

Soy isoflavones are phytochemical constituents of soybeans, a legume that has served as the basis for various foods in many Southeast Asian countries for thousands of years. The major isoflavones in soy are genistein and daidzein. Soyfoods also contain other valuable constituents, including protein, saponins, and phytosterols.

Benefits and uses:

Genistein and daidzein have been well researched by scientists for their antioxidant and estrogenic properties.

Isoflavones may reduce the risk of hormone-dependent cancers, such as breast and prostate cancer, as well as other cancers. A review study of soy research found that 65 percent of 26 animal-based cancer studies showed a protective effect of soy or soy isoflavones. Human research and population studies also suggest that soy can protect against cancer as well as heart disease. The mild estrogen activity of soy isoflavones may ease menopause symptoms for some women, without creating estrogen-related problems, and may help regulate hormone levels in premenopausal women. Soy isoflavones may also play a beneficial role in preventing osteoporosis and autoimmune conditions.

A number of new studies have confirmed anti-cancer effects, more so for genistein than daidzein. Studies have also determined that soy isoflavones can help prevent bone-loss when calcium is deficient, and they can improve blood fat and cholesterol profiles and thus reduce the risk of heart disease.

Two particularly important isoflavones in soy--genistein and daidzein--appear to protect against hormone-related disorders such as breast cancer and endometriosis. They do this by competing for the same place on cells (receptor sites) that the body's own estrogen does. Some of the risks of excess estrogen, including breast and uterine cancer, can apparently be lowered in this way.

Similarly, when the body's natural levels of estrogen drop, as they do with menopause, soy isoflavones can compensate by binding to some of the cell receptor sites that estrogen once did. Menopausal symptoms may improve as a result.

Research findings suggest that soy isoflavones may also inhibit cancer-causing enzymes, provide antioxidant protection, and enhance the immune system.

Specifically, soy isoflavones may help to:

Control symptoms of menopause and perimenopause. When regularly ingested, soy may reduce the frequency and severity of hot flashes and other menopausal difficulties. In one study, women who added 45 grams of soy flour to their daily diet experienced a 40% reduction in hot flashes. The isoflavones in soy are believed to be responsible for these effects.

Guard against osteoporosis. Soy isoflavones may aid women (and men) in maintaining bone mineral density.

One study of postmenopausal women found that consuming 40 grams of soy protein a day resulted in a significant increase in bone mineral density in the spine, an area often weakened by osteoporosis. If the spine is weak, stooped posture and myriad complications may develop.

Counteract the effects of endometriosis. The phytoestrogens in soy products may help to offset the action of the body's natural estrogen, which is often responsible for instigating the monthly pain, heavy bleeding, and other symptoms of endometriosis.

Protect against prostate problems. Eating soy products may protect against enlargement of the male prostate gland. The size of the prostate gland tends to increase with age, causing various types of urinary difficulties, including frequent nighttime awakenings.

Prevent various cancers. Preliminary studies show that regular consumption of soy foods or supplements may protect against hormone-related cancers of the breast, prostate, and endometrium. According to one study, women who ate the most soy products and other foods rich in phytoestrogens reduced their risk of endometrial cancer by 54%.

Integrating soy products may be especially important for women who have never been pregnant. One analysis found that women in this category who consumed little, if any, soy--less than a quarter ounce in a given day, on average--were at four times the risk for developing endometrial cancer. In animal studies, adding soy protein to the diet significantly reduced tumor formation and the likelihood that cancer, once developed, would spread. So even though more research is needed on soy's cancer-fighting properties, researchers are hopeful. They speculate that the isoflavone genistein may block a protein called tyrosine kinase, which promotes the growth and proliferation of tumor cells.

Reduce heart disease risk. Heart-healthy actions have been attributed to isoflavone-rich soy. In 1999 the Food and Drug Administration declared that soy foods can be billed as products that reduce the risk of heart disease by lowering harmful cholesterol.

Specifically, soy products have been shown to lower LDL ("bad") cholesterol and significantly increase HDL ("good") cholesterol.

In one study, people who drank a "milk shake" containing 25 g of soy protein for nine weeks experienced, on average, a 5% reduction in LDL cholesterol. And people with the highest LDL levels experienced an 11% drop. (For each 10% to 15% drop in the LDL level, the risk of a heart attack decreases 20% to 25%.) Because soy's effects are less marked in people with near-normal cholesterol levels, individuals in this category will need to take larger amounts of soy to produce the same reductions. In addition, soy products appear to inhibit the oxidation of LDL cholesterol that can eventually clog arteries.

Active Ingredients:

Isoflavones including genistein, daidzein and glycitein, saponins, phytosterols and protein

Genistein

Synonyms: 4',5,7-Trihydroxyisoflavone
Molecular Formula  C15H10O5
Molecular Weight  270.24
CAS Registry Number  446-72-0
Melting point  297-298°C
Water solubility : insoluble

Daidzein

CAS NO: 486-66-8
PHYSICAL APPEARANCE: pale yellow solid (mp = 315-323°C decomp.)
MOLECULAR FORMULA: C15H10O4
MOLECULAR WEIGHT: 254.2
SOLUBILITY: Soluble in DMSO (25mg/ml) and ethanol (2mg/ml)

Glycitein

Synonyms: 4',7-Dihydroxy-6-methoxyisoflavones 
Molecular Formula  C16H12O5
Molecular Weight  284.26
CAS Registry Number  40957-83-3

Genistin

Name: Genistin
Synonyms: 4',5,7-Trihydroxyisoflavone 7-Glucoside
Molecular Formula  C21H20O10
Molecular Weight  432.38
CAS Registry Number  529-59-9

Daidzin

Synonym: Daidzein-7-O-β-D-glucopyranoside
Molecular Formula: C21H20O9
Molecular Weight: 416.38
CAS Number: 552-66-9

Glycitin

CAS Registry Number: 40246-10-4
Molecular Weight: 446.41
Molecular Formula: C22H22O10

HPLC Chromatogram of vinpocetine

Why AMA Industries Inc. vinpocetine

• A.) AMA Industries Inc. soybean isoflavones is 100% extracted from natural soybean, very safe and more bioactive.
• B.) AMA Industries Inc’s soybean isoflavones has the high purity to meet your body needs.
• C.) AMA Industries Inc. soybean isoflavones almost have no unpleasant taste compare to others and it can be easier to take by oral.
• D.) AMA Industries Inc. offer soybean isoflavones at a very lower price with a very high and uniform quality.
• E.) More important --- we have a very large output to meet our customers’ big and continual orders.

AMA Soybean Extracts product series:

• Soybean Powder
• Soybean Extract Powder 100% water soluble
• Soybean Extract Powder 5% Isoflavones
• Soybean Extract Powder 10% Isoflavones
• Soybean Extract Powder 20% Isoflavones
• Soybean Extract Powder 30% Isoflavones
• Soybean Extract Powder 40% Isoflavones
• Soybean Extract Powder 80% Isoflavones
• Soybean Extract Powder 90% Isoflavones
• Soybean Extract Powder 98% Isoflavones

Reference:

1. Wei, H., et al., "Antioxidant and antipromotional effects of the soybean isoflavone genistein," Proc Soc Exp Biol Med (1995), 208:124–29
2. Arora, A., et al., "Antioxidant activities of isoflavones and their biological metabolites in a liposomal system," Arch Biochem Biophys (1998), 356(2):133–41
3. Messina, M.J., et al., "Soy intake and cancer risk: a review of the in vitro and in vivo data," Nutri Cancer (1994), 21:113–31
4. Messina, M., "To recommend or not to recommend soy foods," J Am Diet Assoc (1994), 94(11):1253–54
5. Menon, L.G., et al., "Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells," Nutr Cancer (1998), 30(1):74–77
6. Onazawa, M., et al., "Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP," Jpn J Clin Oncol (1998), 28(6):360–63
7. Ishida, H., et al., "Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficienct diet," Biol Pharm Bull (1998), 21(1):62–66
8. Baum, J.A., et al., "Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density- lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women," Am J Clin Nutr (1998), 68(3):545–51