Basic information of St. John's Wort Extract

St. John's wort is a plant with yellow flowers.
Common Names--St. John's wort, hypericum, Klamath weed, goat weed
Latin Name--Hypericum perforatum

Ingredients:

Hypericin Pseudohypericin Protohypericin Protopseudohypericin
Kampferol Luteolin Hyperforin Adhyperforin

Hypericin:

Name: Hypericin
CAS Number: 548-04-9
Synonyms:1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione.
Chemical Formula: C30H16O8
Appearance Black crystalls
Molecular Weight 504.5
Melting 320'c
Solubility Ethanol, Ethanol, Dichloromethane

Pseudohypericin:

Name: Pseudohypericin
Molecular Formula:C30H16O9
Molecular Weight 520.44
CAS Registry Number 55954-61-5
Form: solid, black powder 
Storage: Stable for at least one year, stored at -20° C protected from light
Solubility: good soluble in methanol, ethanol, pyridin, DMSO, aceton 

Hyperforin:

Name: Hyperforin
Solubility: 0.25 mg/mL in methanol, solution 
Molecular Formula: C35H52O4
Molecular Weight: 536.78
CAS Number 11079-53-1

What It Is Used For

St. John's wort has been used for centuries to treat mental disorders and nerve pain.
In ancient times, herbalists wrote about its use as a sedative and a treatment for malaria, as well as a balm for wounds, burns, and insect bites.

Today, St. John's wort is used by some for depression, anxiety, and/or sleep disorders.

1. Depression -- St. John's wort is helpful in the therapy of mild to moderate depression with fewer side effects than conventional pharmaceutical antidepressants. The effect of St. John's wort may be noticed the first day, but often it takes a few days or weeks for the full benefits of St. John's wort to occur. Some studies indicate that St. John's wort may be as good an antidepressant as some of the SSRIs such as Prozac and Zoloft. A 6 week double blind study using a combination of St. John's wort, valenian, and passion flower found the combination to be effective in treating mild depression. The dosage used was 360 mg for St. John's wort, 160 mg for valerian, and 190 for passionflower taken once daily. Other supplements used for depression include 5-HTP which is a serotonin precursor, SAM-e which is very potent and needs to be used in low dosages, and Tryptophan, which converts into serotonin. If your doctor approves, you can take one capsule of St. John's wort in the morning and half a capsule of a 50 mg 5 HTP in the afternoon or evening. Some people find the low dose combination of 5 HTP and St. John's wort to be helpful. 
2. PMS -- St. John's wort has been found to be partially helpful in treating PMS.
3. Weight loss -- St. john's wort may be helpful in appetite control when combined with other natural supplements.
4. Somatoform disorders

How It Is Used

The flowering tops of St. John's wort are used to prepare teas and tablets containing concentrated extracts.

What the Science Says

There is some scientific evidence that St. John's wort is useful for treating mild to moderate depression.
However, two large studies, one sponsored by NCCAM, showed that the herb was no more effective than placebo in treating major depression of moderate severity.
NCCAM is studying the use of St. John's wort in a wider spectrum of mood disorders, including minor depression.

Side Effects and Cautions

St. John's wort may cause increased sensitivity to sunlight. Other side effects can include anxiety, dry mouth, dizziness, gastrointestinal symptoms, fatigue, headache, or sexual dysfunction.

Research shows that St. John's wort interacts with some drugs. The herb affects the way the body processes or breaks down many drugs; in some cases, it may speed or slow a drug's breakdown. Drugs that can be affected include:

Indinavir and possibly other drugs used to control HIV infection

Irinotecan and possibly other drugs used to treat cancer
Cyclosporine, which prevents the body from rejecting transplanted organs
Digoxin, which strengthens heart muscle contractions
Warfarin and related anticoagulants
Birth control pills

Antidepressants

When combined with certain antidepressants, St. John's wort may increase side effects such as nausea, anxiety, headache, and confusion. St. John's wort is not a proven therapy for depression. If depression is not adequately treated, it can become severe. Anyone who may have depression should see a health care provider. There are effective proven therapies available. It is important to inform your health care providers about any herb or dietary supplementA product that contains vitamins,minerals, herbs or other botanicals, amino acids, enzymes, and/or other ingredients intended to supplement the diet.

The U.S. Food and Drug Administration has special labeling requirements for dietary supplements and treats them as foods, not drugs. you are using, including St. John's wort. This helps to ensure safe and coordinated care.

HPLC spectrum of St. John’s Wort Extract:

AMA Industries Inc. St. John's Wort Extract series:

• St. John's Wort Extract 0.3% Hypericin
• St. John's Wort Extract 0.3% Hypericin 3% Hyperforin
• St. John's Wort Extract 4:1
• St. John's Wort 100% water soluble extract

Why AMA Industries Inc. St. John's Wort Extract:

• A.) AMA Industries Inc. SJWE is 100% extracted from natural st. john wort plant, very safe and more bioactive.
• B.) AMA Industries Inc. SJWE almost have no unpleasant taste compare to other SJWE and it can be easier to take by oral.
• C.) AMA Industries Inc. offer SJWE at a very lower price with a very high and uniform quality.
• D.) More important --- we have a very large output to meet our customers’ big and continual orders.

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